钱萍-化学化工学院

姓名	钱萍	性别	女
职称	教授	学位	理学博士
联系电话	15605387281
移动电话	15605387281
电子邮箱	qianp@lnnu.edu.cn
联系地址	辽宁省大连市沙河口区黄河路850# 辽宁师范大学化学化工学院

学习经历
1	1997.09—2001.07	辽宁师范大学化学化工学院应用化学专业，本科生，获理学学士学位，导师：姜远良
2	2001.09—2006.10	辽宁师范大学化学化工学院物理化学专业，硕博连读，获理学博士学位，导师：杨忠志
3	2015.02—2016.06	美国田纳西大学/橡树岭国家重点实验室，访问学者

工作经历
1	2006.10—2010.06	山东农业大学化学与材料科学学院，讲师
2	2010.07—2022.12	山东农业大学化学与材料科学学院，副教授
3	2023.01—2026.03	山东农业大学化学与材料科学学院，教授
4	2026.03—至今	辽宁师范大学化学化工学院，教授

个人概况

研究方向：（1）生物大分子体系的多尺度计算机模拟；（2）粘土-水分子体系的力场模型建立及分子动力学模拟研究。

研究生课程：讲授研究生的《高等物理化学》、《应用量子化学》等课程。

本科生课程：讲授本科生的《无机及分析化学1》、《基础化学实验1&2》、《结构化学》等课程。

详细介绍

钱萍，教授，博士生导师。曾获山东农业大学第四届青年教师讲课技能比赛一等奖第一名、山东省首届微课比赛三等奖、山东农业大学“教学质量奖”二等奖、山东农业大学“我最喜欢的专业课老师”荣誉称号、山东农业大学第二届教学先锋先进个人、山东农业大学“巾帼建功先进个人”荣誉称号等。先后主持国家自然科学基金和山东省自然科学基金，以第一作者或通讯作者在《ACS Catalysis》，《Journal of Chemical Theory and Computation》，《Journal of Chemical Information and Modeling》，《Communication Chemistry - Nature》，《Protein Science》等国际著名期刊上发表SCI 论文近50篇。

论文
1	Deng H, Ma Y, Ren WS, Vuong VQ, Qian P, Guo H Structure and Dynamics of the Reactive State for the Histidine Methylation Process and Catalytic Mechanism of SETD3: Insights from Quantum Mechanics/Molecular Mechanics Investigation. ACS Catalysis 2020, 10: 13314-13322.
2	Zhao YY, Xu XL, Deng H, Wang KN, Rahman A, Ma Y, Shaik F, Wang CM, Qian P, Guo H Structural and Energetic Origin of Different Product Specificities and Activities for SETD3 and Its Mutants on the Methylation of the β‑Actin H73K Peptide: Insights from a QM/MM Study. Journal of Chemical Theory and Computation 2023, 19: 349-362.
3	Ren WS, Rahman A, Jiang KB, Deng H, Zhao YY, Zhang WJ, Liu K, Qian P, Guo H, Unraveling the Origins of Changing Product Specificity Properties of Arginine Methyltransferase PRMT7 by the E181D and E181D/Q329A Mutations through QM/MM MD and Free-Energy Simulations. Journal of Chemical Theory and Computation 2022, 18, 2631-2641.
4	Ren WS, Jiang KB, Deng H, Lu N, Yu T, Guo H, Qian P Catalytic Mechanism and Product Specificity of Protein Arginine Methyltransferase PRMT7: A Study from QM/MM Molecular Dynamics and Free Energy Simulations. Journal of Chemical Theory and Computation 2020, 16, 5301-5312.
5	Qian P, Guo HB, Wang L, Guo H QM/MM Investigation of Substrate and Product Speciﬁcities of Suv420h2: How Does This Enzyme Generate Dimethylated H4K20 from Monomethylated Substrate? Journal of Chemical Theory and Computation 2017, 13: 2977-2986.
6	Hintzen JCJ, Ma H, Deng H, Witecha A, Andersen SB, Drozak J, Guo H, Qian P, Li H, Mecinović J* Histidine Methyltransferase SETD3 Methylates Structurally Diverse Histidine Mimics in Actin. Protein Science 2022, 31: e4305.
7	Al Temimi AHK, Amatdjais-Groenen HIV, Vijayendar Reddy Y, Blaauw RH, Guo H, Qian P, Mecinović J The Nucleophilic Amino Group of Lysine is Central for Histone Lysine Methyltransferase Catalysis. Communications Chemistry – Nature 2019, 2: 112.
8	Al Temimi AHK, van der Wekken-de Bruijne R, Proietti G, Guo H, Qian P, Mecinović J γ Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones. Bioconjugate Chemistry 2019, 30, 1798-1804.
9	Yue YF, Ma Y, Qian P, Guo H Catalytic Mechanism of the Ubiquitin-Like NEDD8 Transfer in RING E3-E2∼NEDD8-Target Complex from QM/MM Free Energy Simulations. Journal of Chemical Information and Modeling, 2018, 58: 422-429.
10	Qian P, Guo HB, Yue YF, Wang L, Yang XH, Guo H Understanding the Catalytic Mechanism of Xanthosine Methyltransferase in Caﬀeine Biosynthesis from QM/MM Molecular Dynamics and Free Energy Simulations. Journal of Chemical Information and Modeling 2016, 56: 1755-1761.

项目
1	国家自然科学基金面上项目：基于极化力场和多尺度模拟研究组蛋白翻译后修饰crosstalk对Dot1/Dot1L酶活性的调控机制，2022.01-2025.12 主持
2	国家自然科学基金青年项目：粘土-水分子体系力场模型的建立与分子动力学模拟，2010.01-2012.12 主持
3	山东省自然科学基金面上项目：基于多尺度模拟和生物学实验研究组蛋白泛素化修饰对 Dot1L 甲基化活性的调控机制，2022.01-2024.12 主持
4	山东省自然科学基金面上项目：蛋白质精氨酸甲基转移酶产物特异性的理论模拟与实验研究，2017.08-2020.06 主持

获奖
1	2021-09 山东农业大学“教学质量奖”二等奖
2	2018-09 山东农业大学“我最喜欢的专业课老师”荣誉称号
3	2013-09 山东农业大学第二届教学先锋先进个人
4	2013-08 山东省高等学校教师首届微课教学比赛三等奖
5	2012-09 山东农业大学第四届青年教师讲课技能比赛一等奖
6	2011-05 山东农业大学“五·四青年岗位能手”称号
7	2011-03 山东农业大学“巾帼建功先进个人”荣誉称号

论文
1	Deng H, Ma Y, Ren WS, Vuong VQ, Qian P, Guo H Structure and Dynamics of the Reactive State for the Histidine Methylation Process and Catalytic Mechanism of SETD3: Insights from Quantum Mechanics/Molecular Mechanics Investigation. ACS Catalysis 2020, 10: 13314-13322.
2	Zhao YY, Xu XL, Deng H, Wang KN, Rahman A, Ma Y, Shaik F, Wang CM, Qian P, Guo H Structural and Energetic Origin of Different Product Specificities and Activities for SETD3 and Its Mutants on the Methylation of the β‑Actin H73K Peptide: Insights from a QM/MM Study. Journal of Chemical Theory and Computation 2023, 19: 349-362.
3	Ren WS, Rahman A, Jiang KB, Deng H, Zhao YY, Zhang WJ, Liu K, Qian P, Guo H, Unraveling the Origins of Changing Product Specificity Properties of Arginine Methyltransferase PRMT7 by the E181D and E181D/Q329A Mutations through QM/MM MD and Free-Energy Simulations. Journal of Chemical Theory and Computation 2022, 18, 2631-2641.
4	Ren WS, Jiang KB, Deng H, Lu N, Yu T, Guo H, Qian P Catalytic Mechanism and Product Specificity of Protein Arginine Methyltransferase PRMT7: A Study from QM/MM Molecular Dynamics and Free Energy Simulations. Journal of Chemical Theory and Computation 2020, 16, 5301-5312.
5	Qian P, Guo HB, Wang L, Guo H QM/MM Investigation of Substrate and Product Speciﬁcities of Suv420h2: How Does This Enzyme Generate Dimethylated H4K20 from Monomethylated Substrate? Journal of Chemical Theory and Computation 2017, 13: 2977-2986.
6	Hintzen JCJ, Ma H, Deng H, Witecha A, Andersen SB, Drozak J, Guo H, Qian P, Li H, Mecinović J* Histidine Methyltransferase SETD3 Methylates Structurally Diverse Histidine Mimics in Actin. Protein Science 2022, 31: e4305.
7	Al Temimi AHK, Amatdjais-Groenen HIV, Vijayendar Reddy Y, Blaauw RH, Guo H, Qian P, Mecinović J The Nucleophilic Amino Group of Lysine is Central for Histone Lysine Methyltransferase Catalysis. Communications Chemistry – Nature 2019, 2: 112.
8	Al Temimi AHK, van der Wekken-de Bruijne R, Proietti G, Guo H, Qian P, Mecinović J γ Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones. Bioconjugate Chemistry 2019, 30, 1798-1804.
9	Yue YF, Ma Y, Qian P, Guo H Catalytic Mechanism of the Ubiquitin-Like NEDD8 Transfer in RING E3-E2∼NEDD8-Target Complex from QM/MM Free Energy Simulations. Journal of Chemical Information and Modeling, 2018, 58: 422-429.
10	Qian P, Guo HB, Yue YF, Wang L, Yang XH, Guo H Understanding the Catalytic Mechanism of Xanthosine Methyltransferase in Caﬀeine Biosynthesis from QM/MM Molecular Dynamics and Free Energy Simulations. Journal of Chemical Information and Modeling 2016, 56: 1755-1761.